logo

korean english

게시판

Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.


4시 20분부터 제1과학관 31214 e+강의실에서 간단한 다과를 제공합니다.


                       아      래


Title: Ribocomputing: Cellular Logic Computation using RNA Devices


Speaker: 김  종  민 교수님 (포항공과대학교 생명과학과)


Date & Time: June. 12. (Wed.) 2019 4:30 PM


Place: Natural Science 1,  Room No. 31214


Abstract: Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. Despite many advances, technical challenges remain for scaling up the complexity of these networks due to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and substantial resource requirements for encoding and operation. Here, we report a strategy for constructing RNA-only nanodevices to evaluate complex logic in living cells. Such ‘ribocomputing’ systems are composed of de novo designed parts and operate via predictable and designable base-pairing rules, allowing for effective in silico design of computing devices with prescribed configurations and functions in complex cellular environments. We demonstrate that these ribocomputing devices in Escherichia coli can evaluate two-input logic expressions with dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and a complex 12-input logic expression [1]. Successful operation of ribocomputing devices based on programmable RNA interactions suggests that systems employing the same design principles could be implemented in other host organisms or in extracellular settings.

 

Input RNAs.jpg



References
[1] Green AA*, Kim J*, Ma D, Silver PA, Collins JJ, Yin P, Complex cellular logic computation using ribocomputing devices, Nature 548:117–121, 2017.

 

번호 제목 날짜 조회 수
공지 2019학년도 2학기 콜로퀴움 일정 2019.07.17 76079
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 161227
26 <Mar.27(Wed.)> Ultrafast Movie Maker for Photo-induced Dynamics: Ultrafast Electron Microscope 2019.03.20 5820
25 <April.3(Wed.)> 전자구조계산을 이용한 새로운 양자물질 연구 2019.03.27 5524
24 <April.10(Wed.)> 자성 반데르발스 물질 발견과 전망(Discovery and Perspective of magnetic van der Waals materials) 2019.04.04 5527
23 <April.17(Wed.)> Emerging Artificial Synapse for Learning- and Energy-Efficient Neuromorphic System 2019.04.11 5475
22 <May.1(Wed.)> Introduction of AMS Application 2019.04.24 5524
21 <May.8(Wed.)> Genesis of Matter 2019.05.01 5258
20 <5/16(Thu.) 14:00 ~ >The Chiral anomaly without Landau levels 2019.05.08 4298
19 <May.15(Wed.)> Three-body problems and three-body forces in Classic and Quantum Systems 2019.05.08 5344
18 <May.22(Wed.)> Introduction to exotic quantum states in solids 2019.05.15 5407
17 <June.5(Wed.)> Fluid gravity duality 2019.05.29 5264
» <June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices file 2019.06.07 5142
15 <8/19(Mon) 14:00 ~ >Exploring topological matter in an atomic quantum simulator file 2019.07.26 4404
14 <8/14(Wed.)>3D-strain induced superconductivity in La2CuO4+δ using a simple vertically aligned nanocomposite approach 2019.08.13 4006
13 <8/19(Mon) 13:30 ~ >Detection of cosmic rays in the PeV to EeV energy range file 2019.08.16 3857
12 <8/26(Mon) 14:00 ~ >Constructing viable models of bouncing scenarios 2019.08.20 3780
11 <8/30(Fri) 16:00 ~ >Structures of light neutron-rich nuclei, 17,19C 2019.08.22 3786
10 <9/2(Mon) 15:00 ~ >Status of the KM3NeT Deep Sea Neutrino Telescope 2019.08.26 3577
9 <Sept.11(Wed.)> Fantastic physics and materials, how to find them? 2019.09.06 3507
8 <9/17(Tue) 4:00 pm ~ >Dynamics of multiple-Q spin textures and its effect on electronic state 2019.09.10 3114