korean english


Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.

4시 20분부터 제1과학관 31214 e+강의실에서 간단한 다과를 제공합니다.

                       아      래

Title: Ribocomputing: Cellular Logic Computation using RNA Devices

Speaker: 김  종  민 교수님 (포항공과대학교 생명과학과)

Date & Time: June. 12. (Wed.) 2019 4:30 PM

Place: Natural Science 1,  Room No. 31214

Abstract: Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. Despite many advances, technical challenges remain for scaling up the complexity of these networks due to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and substantial resource requirements for encoding and operation. Here, we report a strategy for constructing RNA-only nanodevices to evaluate complex logic in living cells. Such ‘ribocomputing’ systems are composed of de novo designed parts and operate via predictable and designable base-pairing rules, allowing for effective in silico design of computing devices with prescribed configurations and functions in complex cellular environments. We demonstrate that these ribocomputing devices in Escherichia coli can evaluate two-input logic expressions with dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and a complex 12-input logic expression [1]. Successful operation of ribocomputing devices based on programmable RNA interactions suggests that systems employing the same design principles could be implemented in other host organisms or in extracellular settings.


Input RNAs.jpg

[1] Green AA*, Kim J*, Ma D, Silver PA, Collins JJ, Yin P, Complex cellular logic computation using ribocomputing devices, Nature 548:117–121, 2017.


번호 제목 날짜 조회 수
공지 2020학년도 1학기 콜로퀴움 일정 2020.01.31 205827
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 529223
617 <2/17(Mon.)> Magneto-optical study of the Dirac semimetal Cd3As2 in Voigt geometry 2020.02.11 10168
616 <Dec.11(Wed.)>데이터 과학으로서의 물리학. 그리고 금융투자업 2019.12.04 13098
615 <12/17(Tue.)> Nuclear spectroscopy with low energy reaction thermal neutrons in ILL 2019.12.17 13428
614 <12/10(Tue.)> Investigating dark matter signals at neutrino telescopes 2019.12.06 14138
613 <12/6(Fri.)>topological phase transitions in Kitaev quantum spin liquids. 2019.12.04 14297
612 <Nov.20(Wed.)>At the End of Space and Time: Imaging the Black Hole in M 87 2019.11.14 16574
611 <Dec.4(Wed.)>2D materials based metasurfaces & THz near-field spectroscopy 2019.11.27 16733
610 <Nov.13(Wed.)>The Science of Quark-Gluon Plasma 2019.11.06 16812
609 <Oct.30(Wed.)> 왼손과 오른손, 기본 입자와 끈 2019.10.24 18232
608 <10/22(Tue.)>To p or not to p? – 17O NMR of Sr2RuO4 under strain file 2019.10.17 18336
607 <10/1(Tue.) Mini-Workshop on BSM Physics with Neutrino Detectors 2019.09.30 18707
606 <9/24(Tue) 4:00 pm ~ > Structure Formation with Two Periods of Inflation: Beyond plain LCDM 2019.09.17 19347
605 <9/26(Thu.) 4:30 pm ~ > Neutrino Physics and Dark Matter search in IBS 2019.09.24 19771
604 <9/17(Tue) 4:00 pm ~ >Dynamics of multiple-Q spin textures and its effect on electronic state 2019.09.10 20319
603 <9/2(Mon) 15:00 ~ >Status of the KM3NeT Deep Sea Neutrino Telescope 2019.08.26 20653
602 <Oct.2(Wed.)> Fundamental physics with high-energy atmospheric and cosmic neutrinos today and in the future 2019.09.26 20735
601 <8/30(Fri) 16:00 ~ >Structures of light neutron-rich nuclei, 17,19C 2019.08.22 20924
600 <8/26(Mon) 14:00 ~ >Constructing viable models of bouncing scenarios 2019.08.20 21035
599 <Oct.16(Wed.)> 솟구치는 초고에너지 입자의 미스테리 2019.10.10 21288
598 <8/19(Mon) 13:30 ~ >Detection of cosmic rays in the PeV to EeV energy range file 2019.08.16 21302