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이번 학기 콜로퀴움은 코로나19 재유행 대비 상황에 따라 온-오프 하이브리드(오프라인+Real Time Streaming)으로 운영될 예정입니다.

다섯 번째 강연에는 부산대학교 이상학 교수님을 모시고 콜로퀴움을 개최하오니, 학과 구성원 여러분의 많은 참여를 부탁 드립니다.



                                       아            래



1. Title: Neurodegenerative Diseases from the Chemical Force Point of View


2. Speaker: 이  상  학  교수님 (부산대학교, 화학과)


3. Date & Time: Oct. 12(Wed.) 2022.  4:30 PM

 
4. Place: Natural Science 1,  Room No. 31214


5. Abstract: Protein aggregation, also referred to as phase separation, has been the subject of much research in biology, biophysics, and chemistry. Protein aggregation can function either to promote normal cellular metabolism or to disturb normal cellular functions. The chemical mechanism underlying protein aggregation is not clearly understood. It is well-known that many aggregated proteins are highly charged, either positively or negatively. Thus, we hypothesized that protein aggregation is mediated by small charged biomolecules: negatively charged nucleoside triphosphate (NTP) interacting with positively charged proteins and positively charged polyamine interacting with negatively charged proteins. In this study, we employed super-charged green fluorescence protein (scGFP) to study how charged proteins are aggregated through charge-charge interaction with small charged biomolecules in cells. When expressing scGFP in E-coli, positively charged (+28) GFPs were found to aggregate with NTP and negatively charged (-27) GFPs aggregated with polyamine molecules. In addition, it is known that tau protein aggregation is a main cause of neuronal dementia, Alzheimer’s disease. We showed tau proteins could be aggregated by small charged molecules. We thereby conclude that the small charged biomolecules are the main driver to induce protein aggregation in cells. 


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