logo

korean english

게시판

Home > 게시판 > 세미나

콜럼비아대학교의 이자일 박사님을 초청하여 아래와 같이 특별 세미나를 개최합니다.

학과 구성원 여러분의 많은 참석을 부탁 드립니다. 

 

         아             래  

 

     1. 일시: 2013년 4월 30일(화) 오후 4시 30분 

 

     2. 장소: 제1과학관 기초과학연구소세미나실 31317호

 

     3. 연사: 이  자  일  박사님 (Columbia University

 

     4. 제목: DC (DNA Curtains) and AC (Actin Curtains) in single-molecule biophysics

 

     5. 초록: Single-molecule biophysics provides powerful tools for investigating in-depth biological phenomena that cannot be uncovered by conventional biophysical and biochemical methods. A variety of single-molecule methods have been developed and are rapidly expanding their realms. Here I introduce two novel single-molecule techniques, DNA curtains (DC) and actin curtains (AC), both of which provide in vitro platforms to study biopolymers and associated proteins based on the integration of lipid bilayer fluidity, microfluidics, total internal reflection fluorescence microscopy (TIRFM), and nano-technology. The advantages of these techniques are 1) visualizing individual bio-molecules in real time, 2) observing hundreds of bio-molecules within one field-of-view, which are responsible for the statistical reliability, and 3) offering a bio-compatible environment through the membrane bilayer. With the help of DNA curtains the activities of FtsK are examined, which is a DNA translocase moving along double-stranded DNA. The DNA curtains assay demonstrates that FtsK is assembled on a specific DNA sequence, translocates along DNA rapidly and processively, and displaces protein roadblocks during translocation. The results give an insight into the biological function of FtsK in the E. coli cell division and chromosome segregation. On the other hand, the actin curtains technique enables one to characterize actin filament growth by a formin, which enhances actin nucleation. Moreover, under the hydrodynamic flow, the polymerization of actin filaments increases force applied to the formins. This allows one to examine the force effect on the formin-mediated actin polymerization. Surprisingly, the force reduces the formin-mediated actin polymerization rate without any cofactor, whereas the polymerization rate is increased by force in the presence of a cofactor, profilin.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1058838
162 <7/25(목) 오전11시> 물리학과 특별세미나 개최 안내 2013.07.19 112478
161 <6/25(화)>물리학과 특별세미나 개최 안내 2013.06.24 136681
» <4/30(화)> DC (DNA Curtains) and AC (Actin Curtains) in single-molecule biophysics 2013.04.11 112457
159 <3/27> The Born series for S-wave spin-quartet neutron-deuteron scattering at small cutoff values. 2013.03.25 77761
158 <3/12(화)>물리학과 특별초청강연 개최 안내 2013.03.04 116663
157 <2/7>Emergent p-wave Kondo Coupling in Multi-Orbital Bands with Mirror Symmetry Breaking 2013.02.06 70863
156 <2/7> Exotic phases in pyrochlore iridates 2013.02.05 65354
155 <1/16> Higgs-to-diphoton rate in type II seesaw models 2013.01.11 73724
154 <12/12> lattice structure in holographic models 2012.12.12 73311
153 <12/21(금)> Theory of topological quantum phase transitions in 3D noncentrosymmetric systems 2012.12.05 122067
152 <12/21(금)> Generic quantum spin ice 2012.12.03 66664
151 <11/28> Extremal Black Holes and Holographic C-theorem 2012.11.28 97101
150 <12/3> Magnetic couplings, optical spectra, and spin-orbit exciton in 5d Mott insulator Sr2IrO4 2012.11.26 95688
149 <11/21> Cosmological viable scalar-tensor theories of gravity 2012.11.16 180570
148 <11/5> Optical spectroscopic probe on the surface state in three dimensional topological insulators 2012.10.24 69328
147 <10/24> Dung-hai Lee 교수와의 간담회 2012.10.23 67506
146 <11/22> Spin polarization of photoelectrons from a topological insulator 2012.10.22 63226
145 <10/23> Measuring Transfer Reactions with Radioactive Beams 2012.10.15 73896
144 <10/12> Kondo Effect in a Quantum-Dot-Topological-Superconductor Junction: A Numerical Renormalization Group Analysis 2012.10.08 74931
143 <10/5> Gauge fields. Past, present, future. 2012.10.05 64708