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아 래
제목: In vivo optical imaging of hemodynamic changes as a surrogate signal of neuronal activity in the
neocortex
연사: 서 민 아 교수(성균관대학교 생명과학과)
일시: 2009년 5월 1일(금) 오후4:30
장소: 물리학과 세미나실(31355호실)
초록: Optical imaging offers excellent spatio-temporal sensitivity that is unparalleled by any other
perfusion based imaging techniques. We used in vivo optical recording of intrinsic signals (ORIS) to
map neurovascular hemodynamics of perfusion, oximetry and membrane potential during epileptic
events in rat and mouse neocortex. Studies of hemodynamic changes with ORIS alone were also
performed in human. Laboratory studies in rodent epilepsy models have demonstrated a persistent
increase in deoxygenated hemoglobin (Hbr) and a decrease in tissue oxygenation during interictal
spikes and ictal events. This “epileptic dip”, like the “initial dip” recorded during normal sensory
processing, implies that the enormous rise in cerebral blood flow (CBF) is inadequate to meet the
increased metabolic demands associated with synchronized epileptic activity. These findings are
critically important to the interpretation of the perfusion-based imaging studies, such as fMRI. In
addition, we visualized the effect of direct cortical electrical stimulation, an alterative epilepsy
treatment. The optical data following direct cortical electrical stimulation showed that hemodynamic
signals are sensitive to different electrical stimulation parameters. Furthermore, our recent data
demonstrated that the application of unilateral electrical stimulation is able to elicit bilateral
hemodynamic responses in rat neocortex.
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http://physics.skku.ac.kr/ppt/090501.ppt