logo

korean english

게시판

Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.


4시 20분부터 제1과학관 31214 e+강의실에서 간단한 다과를 제공합니다.


                       아      래


Title: Ribocomputing: Cellular Logic Computation using RNA Devices


Speaker: 김  종  민 교수님 (포항공과대학교 생명과학과)


Date & Time: June. 12. (Wed.) 2019 4:30 PM


Place: Natural Science 1,  Room No. 31214


Abstract: Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. Despite many advances, technical challenges remain for scaling up the complexity of these networks due to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and substantial resource requirements for encoding and operation. Here, we report a strategy for constructing RNA-only nanodevices to evaluate complex logic in living cells. Such ‘ribocomputing’ systems are composed of de novo designed parts and operate via predictable and designable base-pairing rules, allowing for effective in silico design of computing devices with prescribed configurations and functions in complex cellular environments. We demonstrate that these ribocomputing devices in Escherichia coli can evaluate two-input logic expressions with dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and a complex 12-input logic expression [1]. Successful operation of ribocomputing devices based on programmable RNA interactions suggests that systems employing the same design principles could be implemented in other host organisms or in extracellular settings.

 

Input RNAs.jpg



References
[1] Green AA*, Kim J*, Ma D, Silver PA, Collins JJ, Yin P, Complex cellular logic computation using ribocomputing devices, Nature 548:117–121, 2017.

 

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1058973
386 2019학년도 2학기 콜로퀴움 일정 2019.07.17 424875
385 <Mar.3(Wed.)>Scaling laws in Natural Language Processing 2021.02.25 321442
384 2017학년도 1학기 콜로퀴움 일정 2017.01.05 284561
383 2020학년도 1학기 콜로퀴움 일정 2020.01.31 253329
382 <5/16> 물리학자가 바라 본 단백질: 왜, 어떻게 연구하는가? 2012.05.10 253295
381 <6/11> Advanced Physiological Optics and Its Ophthalmic Applications 2014.05.28 236361
380 <3/14>Adaptive Optics for the Human Eye and Ophthalmic Applications 2008.03.12 236149
379 <11/6> Graphene plasmon and Plasmonics 2013.10.31 235835
» <June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices file 2019.06.07 210801
377 <Sep. 23(Wed.) 4:30 PM>Grain boundary effect in Metal : A journey of discovery from crystal to thin films without grain boundaries 2015.09.16 199530
376 <Dec. 1(Wed.)>Halide Perovskite Single Crystals and Thin Films for Solar Cells and Optoelectronics 2021.11.25 190353
375 <11/26(수)> Neutrino Physics with KamLAND 2014.11.20 190247
374 <Nov. 16(Wed.) 4:30 PM> Two-dimensional Chiral Materials and Topological Insulators 2016.11.10 189635
373 <Oct. 7(Wed.) 4:30 PM> Observing Ultra High Energy Cosmic Rays with your Smartphone 2015.10.02 184797
372 <10/31> Large-Scale Quantitative Analysis of Painting Arts 2012.10.18 179974
371 <Nov. 18(Wed.) 4:30 PM> Single-molecule chemistry and spectroscopy on ultrathin insulating films 2015.11.11 178238
370 <12/4> Shining light on the dark Universe 2013.11.29 176318
369 <May. 25(Wed.) 4:30 PM> Functional Materials @ Nanoscale: Electronics, Energy and ‘Green’Healthcare Applications 2016.05.23 175946
368 <4/2> Radio Detection of Ultra High Energy Cosmic Rays and Neutrinos in Antarctica 2014.03.26 167674
367 <3/13> Probing hidden magnetism and quantum criticality in unconventional superconductors 2009.03.06 165575