logo

korean english

게시판

Home > 게시판 > 세미나

아래와 같이 세미나를 개최하오니 많이 참석해 주시기 바랍니다.

 

                    아       래

 

제목: Radioprotection effect and anti-tumor immunity by TCM-EF in mice

 

연사: 구  연  화  교수님 (일본, Junshin Gakuen University)

 

일시: 2013. 8. 20(화) 11am
 

장소: 물리학과 세미나실 (31355호실)
 

초록: Various previously intractable diseases have been overcome by the development of many new medicines. However, cancer is still a major cause of death. In the process of carcinogenesis, a multistep accumulation of gene mutations causes malignant transformation, and the probability of gene mutations is different depending on genetic and environmental factors. Individual differences are found in the susceptibility to cancer, and prevention of carcinogenesis is possible. In the lactic acid bacteria in the gut, we directed our attention to TCM-EF, which have been known as using the bacteria death of lactic acid bacteria by heat treatment, and examined the mechanisms by which these substances affect antioxidant activity, anti-tumor activity and immunoresponse.
When the antioxidant activities of TCM-EF were examined by the DPPH and Rhoudan iron methods, since TCM-EF contains high levels of β-glucan, it is thought that β-glucans may be responsible for the immunoenhancement activity in this study. In the examination of immunoenhancement activity, we measured lymphocyte versus polymorophonuclear leukocyte ratios (L/P activity) in the experimental animals. The number of lymphocytes was significantly increased in groups treated with Propolis as a control. Specifically, slightly high levels of IFN-γ were measured in mice bearing the S-180 carcinoma, after administration of TCM-EF. This strongly suggests that cellular immunity is especially activated by treatment with TCM-EF, because production of IFN-γ is known to be limited to the T cells and NK cells stimulated by mitogen and sensitized antigen. When TNF-α levels were measured in mice bearing the S-180 carcinoma, mice treated with TCM-EF showed slightly higher TNF-α levels as compared to the control group. This suggests that activated macrophages produce TNF-α in mice treated with TCM-EF, since activated macrophages and lymphocytes are the source of most TNF-α. When anti-tumor action was examined using two kinds of sarcoma of Ehrlich solid carcinoma and Sarcoma-180 carcinoma, tumor-suppressive ratios after treatment with TCM-EF was 60.3 % and 83.1 %, respectively. Thus, TCM-EF showed strong anti-tumor activity against two kinds of solid carcinoma. Taken altogether, this strongly suggests that TCM-EF enhances original functions of macrophages and NK cells, and as a result, secondarily enhances the immune reaction and suppresses tumor growth.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1058799
662 <9/20> Time-reversal anomaly in Josephson effect involving Majorana fermions 2012.09.20 197624
661 <Dec. 1(Wed.)>Halide Perovskite Single Crystals and Thin Films for Solar Cells and Optoelectronics 2021.11.25 190278
660 <11/26(수)> Neutrino Physics with KamLAND 2014.11.20 190130
659 <Nov. 16(Wed.) 4:30 PM> Two-dimensional Chiral Materials and Topological Insulators 2016.11.10 187691
658 <Oct. 7(Wed.) 4:30 PM> Observing Ultra High Energy Cosmic Rays with your Smartphone 2015.10.02 183811
657 <11/21> Cosmological viable scalar-tensor theories of gravity 2012.11.16 180517
656 <10/31> Large-Scale Quantitative Analysis of Painting Arts 2012.10.18 179303
655 <Nov. 18(Wed.) 4:30 PM> Single-molecule chemistry and spectroscopy on ultrathin insulating films 2015.11.11 178174
654 <12/20(Thu) 2:00pm> Gravitating Spinning Stars (a particle theorist's perspective) 2018.12.17 177169
653 <May. 25(Wed.) 4:30 PM> Functional Materials @ Nanoscale: Electronics, Energy and ‘Green’Healthcare Applications 2016.05.23 175815
652 <12/4> Shining light on the dark Universe 2013.11.29 175721
651 <4/2> Radio Detection of Ultra High Energy Cosmic Rays and Neutrinos in Antarctica 2014.03.26 167344
650 <3/13> Probing hidden magnetism and quantum criticality in unconventional superconductors 2009.03.06 165360
649 <Feb.18(Thu.)> Hund's metallicity in the vicinity of a Van Hove singularity / Correlated topological phases in strongly correlated heterostructures 2021.02.16 162641
648 <4/18> 삼중항 여기자를 이용한 유기광전소자 연구 2012.04.05 162174
647 <12/5> Fluerenes with diversed structures and their applications 2008.12.02 160946
646 <11/7> On-Film Formation of Bi Nanowires with Extraordinary Electron Mobility 2008.11.03 160578
645 <Dec.5(Wed.)> 두 펄사 이야기 2018.11.28 160108
644 <4/18(금)> 양자물질초전도체창의연구소 초청 세미나 2014.04.15 159570
643 <6/2> The black hole search at the LHC: critical comment 2011.06.01 159189