하택집 교수 특별 세미나 “Single Molecule Nanometry “
일리노이대(University of Illinois at Urbana-Champaign) 물리학과 하택집 교수님이 “Single Molecule
Nanometry”라는 주제를 가지고 특별 세미나를 합니다. 일리노이대 물리학과 정교수이며 그리고 “Center for
the Physics of Living Cells” 의 공동 디렉터 이기도 한 하 교수님은 생물물리 분야를 이끌어가는 세계적 리
더중의 한 분입니다. 특별세미나에서는 생물물리의 최근 동향 및 단일 분자 Nanometry에 대해 강연을 할 것
입니다.
장소: 물리학과 세미나실(제1과학관 31355호실)
시간: 2010년 5월 26일(수) 오후 4시
Abstract: Precision measurement is a hallmark of physics but the small length scale (~nanometer) of
elementary biological processes and the thermal fluctuations surrounding them challenge our ability to
visualize the motion of biological molecules. In this talk, I will highlight the recent developments in
single molecule nanometry where a position of a single fluorescent molecule can be determined with a
single nanometer precision, reaching the limited imposed by the shot noise, and the relative motion
between two molecules can be determined with ~0.3 nm precision at ~ 1 milliseconds time resolution,
and how these new tools are providing fundamental insights on how motor proteins move on cellular
highways. Finally, I will show our recent progress in combining angstrom scale optical tweezers with
single molecule fluorescent detection, opening new avenues for multi-dimensional single molecule
nanometry for biological physics.
References:
[1] Yildiz, A., J. Forkey, S. A. McKinney, T. Ha, Y. Goldman, and P. R. Selvin, "Myosin V Walks Hand
over Hand: Single Fluorophore Imaging with 1.5 Nanometer Localization", Science 300(5628), 2061-2065
(2003).
[2] Myong, S., I. Rasnik, C. Joo, T. M. Lohman, and T. Ha, "Repetitive Shuttling of a Motor Protein on
DNA", Nature 437, 1321-1325 (2005).
[3] Hohng, S., R. Zhou, M. K. Nahas, J. Yu, K. Schulten, D. M. J. Lilley and T. Ha, "Fluorescence-
force spectroscopy maps two-dimensional reaction landscape of the Holliday junction", Science 318
(5849), 279-283 (2007).
