아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.
4시 20분부터 제1과학관 31214 e+강의실 앞에서 다과를 준비하오니 많은 참석 부탁드립니다
아 래
제목: Modified nucleic acid systems for biomedical applications
연사: 김 병 현 교수 (포항공대 화학과)
일시: 2010년 11월 5(금) 오후4:30
장소: e+첨단강의실 (31214호실)
초록: Nucleic acid today can be viewed as a chemical reagent, quite apart from its role in
biology, although much of the work is inspired by what might be the positive consequences
for medicine or drug development or diagnosis of disease. For even neglecting its biological
importance, there would still be a lot of interests in nucleic acid as a fundamental molecule
for chemists to study and use as an object for chemical building blocks, sensing, polymer
design and others.1
Nowadays, nucleic acids have been emerged from various research areas such as DNA
computing, nano-size structures using DNA, sensors recognizing mRNA and DNA, and
oligonucleotide therapeutics, and others.2 Chemical modification of nucleic acid systems is
essential to obtain more effective and stable materials. From nucleoside to oligonucleotide,
chemical modification is open to any part of nucleic acid. We focus on the synthesis of new
phosphoramidites to incorporate into the oligonucleotides.
In this seminar, we will discuss our research efforts into oligonucleotides functionalized with
steroid derivatives and cationic amine moieties to enhance their cell permeability.3 We will
also describe about our syntheses of modified oligonucleotides containing fluorescent tags
for use as molecular probes (molecular beacons) to detect single-nucleotide polymorphisim
(SNP) in nucleic acids,4 and to monitor secondary structures of various nucleic acids such
as B-Z transition,5 G-quadruplex structures,6 and DNA i-motif structures.
References
1. Henry, C. M. C&E News 2003, 81, 49-60.
2. (a) Seo, Y. J.; Rhee, H.; Joo, T.; Kim, B. H. J. Am. Chem. Soc. 2007, 129, 5244-5247. (b)
Seo, Y. J.; Bhuniya, S.; Kim, B. H. Chem. Commun. 2007, 1804-1806. (c) Venkatesan, N.; Kim,
B. H. Chem. Rev. 2006, 106, 3712-3761.
3. Seo, Y. J.; Jeong, H. S.; Bang, E. K.; Hwang, G. T.; Jung, J. H.; Jang, S. K.; Kim, B. H.
Bioconjugate Chem. 2006, 17, 1151-1155.
4. (a) Venkatesan, N.; Seo, Y. J.; Kim, B. H. Chem. Soc. Rev. 2008, 37, 648-663. (b) Hwang,
G. T.; Seo, Y. J.; Kim, B. H. J. Am. Chem. Soc. 2004, 126, 6528-6529.
5. Seo, Y. J.; Kim, B. H. Chem. Commun. 2006, 150–152.
6. (a) Seo, Y. J.; Lee, I. J.; Yi, J. W.; Kim, B. H. Chem. Commun. 2007, 2817-2820. (b) Seo, Y.
J.; Lee, I. J.; Kim, B. H. Bioorg. Med. Chem. Lett. 2008, 18, 3910-3913.
