logo

korean english

게시판

Home > 게시판 > 세미나

콜럼비아대학교의 이자일 박사님을 초청하여 아래와 같이 특별 세미나를 개최합니다.

학과 구성원 여러분의 많은 참석을 부탁 드립니다. 

 

         아             래  

 

     1. 일시: 2013년 4월 30일(화) 오후 4시 30분 

 

     2. 장소: 제1과학관 기초과학연구소세미나실 31317호

 

     3. 연사: 이  자  일  박사님 (Columbia University

 

     4. 제목: DC (DNA Curtains) and AC (Actin Curtains) in single-molecule biophysics

 

     5. 초록: Single-molecule biophysics provides powerful tools for investigating in-depth biological phenomena that cannot be uncovered by conventional biophysical and biochemical methods. A variety of single-molecule methods have been developed and are rapidly expanding their realms. Here I introduce two novel single-molecule techniques, DNA curtains (DC) and actin curtains (AC), both of which provide in vitro platforms to study biopolymers and associated proteins based on the integration of lipid bilayer fluidity, microfluidics, total internal reflection fluorescence microscopy (TIRFM), and nano-technology. The advantages of these techniques are 1) visualizing individual bio-molecules in real time, 2) observing hundreds of bio-molecules within one field-of-view, which are responsible for the statistical reliability, and 3) offering a bio-compatible environment through the membrane bilayer. With the help of DNA curtains the activities of FtsK are examined, which is a DNA translocase moving along double-stranded DNA. The DNA curtains assay demonstrates that FtsK is assembled on a specific DNA sequence, translocates along DNA rapidly and processively, and displaces protein roadblocks during translocation. The results give an insight into the biological function of FtsK in the E. coli cell division and chromosome segregation. On the other hand, the actin curtains technique enables one to characterize actin filament growth by a formin, which enhances actin nucleation. Moreover, under the hydrodynamic flow, the polymerization of actin filaments increases force applied to the formins. This allows one to examine the force effect on the formin-mediated actin polymerization. Surprisingly, the force reduces the formin-mediated actin polymerization rate without any cofactor, whereas the polymerization rate is increased by force in the presence of a cofactor, profilin.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1091363
598 <9/2(Mon) 15:00 ~ >Status of the KM3NeT Deep Sea Neutrino Telescope 2019.08.26 84359
597 <8/30(Fri) 16:00 ~ >Structures of light neutron-rich nuclei, 17,19C 2019.08.22 93662
596 <8/26(Mon) 14:00 ~ >Constructing viable models of bouncing scenarios 2019.08.20 60574
595 <8/19(Mon) 13:30 ~ >Detection of cosmic rays in the PeV to EeV energy range file 2019.08.16 102373
594 <8/14(Wed.)>3D-strain induced superconductivity in La2CuO4+δ using a simple vertically aligned nanocomposite approach 2019.08.13 72054
593 <8/19(Mon) 14:00 ~ >Exploring topological matter in an atomic quantum simulator file 2019.07.26 81972
592 2019학년도 2학기 콜로퀴움 일정 2019.07.17 428984
591 <June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices file 2019.06.07 244740
590 <June.5(Wed.)> Fluid gravity duality 2019.05.29 68767
589 <May.22(Wed.)> Introduction to exotic quantum states in solids 2019.05.15 80173
588 <May.15(Wed.)> Three-body problems and three-body forces in Classic and Quantum Systems 2019.05.08 76425
587 <5/16(Thu.) 14:00 ~ >The Chiral anomaly without Landau levels 2019.05.08 140983
586 <May.8(Wed.)> Genesis of Matter 2019.05.01 42243
585 <May.1(Wed.)> Introduction of AMS Application 2019.04.24 70419
584 <April.17(Wed.)> Emerging Artificial Synapse for Learning- and Energy-Efficient Neuromorphic System 2019.04.11 130752
583 <April.10(Wed.)> 자성 반데르발스 물질 발견과 전망(Discovery and Perspective of magnetic van der Waals materials) 2019.04.04 49221
582 <April.3(Wed.)> 전자구조계산을 이용한 새로운 양자물질 연구 2019.03.27 47781
581 <Mar.27(Wed.)> Ultrafast Movie Maker for Photo-induced Dynamics: Ultrafast Electron Microscope 2019.03.20 95813
580 <Mar.20(Wed.)> Connecting Thermoelectricity and Superconductivity by Pressure Bridge 2019.03.13 58802
579 <Mar.13(Wed.)> Physics in Medicine: Magnetic Resonance Imaging 2019.03.07 64439