logo

korean english

게시판

Home > 게시판 > 세미나

콜럼비아대학교의 이자일 박사님을 초청하여 아래와 같이 특별 세미나를 개최합니다.

학과 구성원 여러분의 많은 참석을 부탁 드립니다. 

 

         아             래  

 

     1. 일시: 2013년 4월 30일(화) 오후 4시 30분 

 

     2. 장소: 제1과학관 기초과학연구소세미나실 31317호

 

     3. 연사: 이  자  일  박사님 (Columbia University

 

     4. 제목: DC (DNA Curtains) and AC (Actin Curtains) in single-molecule biophysics

 

     5. 초록: Single-molecule biophysics provides powerful tools for investigating in-depth biological phenomena that cannot be uncovered by conventional biophysical and biochemical methods. A variety of single-molecule methods have been developed and are rapidly expanding their realms. Here I introduce two novel single-molecule techniques, DNA curtains (DC) and actin curtains (AC), both of which provide in vitro platforms to study biopolymers and associated proteins based on the integration of lipid bilayer fluidity, microfluidics, total internal reflection fluorescence microscopy (TIRFM), and nano-technology. The advantages of these techniques are 1) visualizing individual bio-molecules in real time, 2) observing hundreds of bio-molecules within one field-of-view, which are responsible for the statistical reliability, and 3) offering a bio-compatible environment through the membrane bilayer. With the help of DNA curtains the activities of FtsK are examined, which is a DNA translocase moving along double-stranded DNA. The DNA curtains assay demonstrates that FtsK is assembled on a specific DNA sequence, translocates along DNA rapidly and processively, and displaces protein roadblocks during translocation. The results give an insight into the biological function of FtsK in the E. coli cell division and chromosome segregation. On the other hand, the actin curtains technique enables one to characterize actin filament growth by a formin, which enhances actin nucleation. Moreover, under the hydrodynamic flow, the polymerization of actin filaments increases force applied to the formins. This allows one to examine the force effect on the formin-mediated actin polymerization. Surprisingly, the force reduces the formin-mediated actin polymerization rate without any cofactor, whereas the polymerization rate is increased by force in the presence of a cofactor, profilin.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1090427
182 <8/7> Scotch tape and spectroscopy: probing and manipulating the surface of a topological insulator 2012.07.27 94231
181 <2/17(Mon.)> Magneto-optical study of the Dirac semimetal Cd3As2 in Voigt geometry 2020.02.11 94057
180 <2/15> Geometric distance-dependent percolations in networks on two-dimensional planes 2011.02.11 93784
179 <5/22> 정상욱 교수 초청 세미나 Overview of Multiferroics 2006.05.19 93686
178 <8/30(Fri) 16:00 ~ >Structures of light neutron-rich nuclei, 17,19C 2019.08.22 93439
177 <June 30(Wed.)>Mapping of magnetic anisotropy for van der Waals materials 2021.06.25 93032
176 <4/2> Supersymmetric vacua of mass-deformed M2-brane theory 2010.03.29 92891
175 <6/19> Kohn's theorem and non-relativistic symmetry 2012.06.15 92807
174 <6/21> Nuclear Astrophysics in Effective Field Theories 2012.06.20 92544
173 <8/17> Is Quantum Criticality a Key to Unconventional Superconductivity? 2006.08.09 92342
172 <11/4 오전 10:30> Quantum transport through topological-metal strip 2013.10.23 92317
171 <3/26>A perturbative & non-perturbative test of ABJM model 2009.03.19 92273
170 <8/7> Scotch tape and spectroscopy: probing and manipulating the surface of a topological insulator 2012.07.27 92237
169 <6/10> Traffic Problem in Physics and Its Application 2008.06.10 91974
168 <10/1(Tue.) Mini-Workshop on BSM Physics with Neutrino Detectors 2019.09.30 91795
167 <2/15> Perturbation during Inflation 2011.02.11 91741
166 <1/14>Dark Matter signals from PAMELA and ATIC 2009.01.12 91069
165 <3/16(Fri.)11:00> Superlattice phonons of two dimensional heterostructures 2018.03.16 90995
164 <3/13(금) pm1:00> 초청세미나 개최 안내 2015.03.09 90898
163 <2/16>Hamiltonian formalism 2011.02.11 90760