Home > 게시판 > 세미나
아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.
4시 20분부터 제1과학관 31214 e+강의실에서 간단한 다과를 제공합니다.
Title: Ribocomputing: Cellular Logic Computation using RNA Devices
Speaker: 김 종 민 교수님 (포항공과대학교 생명과학과)
Date & Time: June. 12. (Wed.) 2019 4:30 PM
Place: Natural Science 1, Room No. 31214
Abstract: Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. Despite many advances, technical challenges remain for scaling up the complexity of these networks due to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and substantial resource requirements for encoding and operation. Here, we report a strategy for constructing RNA-only nanodevices to evaluate complex logic in living cells. Such ‘ribocomputing’ systems are composed of de novo designed parts and operate via predictable and designable base-pairing rules, allowing for effective in silico design of computing devices with prescribed configurations and functions in complex cellular environments. We demonstrate that these ribocomputing devices in Escherichia coli can evaluate two-input logic expressions with dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and a complex 12-input logic expression . Successful operation of ribocomputing devices based on programmable RNA interactions suggests that systems employing the same design principles could be implemented in other host organisms or in extracellular settings.
 Green AA*, Kim J*, Ma D, Silver PA, Collins JJ, Yin P, Complex cellular logic computation using ribocomputing devices, Nature 548:117–121, 2017.
|공지||<12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생||2016.11.28||1032789|
|346||<Oct.7(Wed.)>Organic Photodiode for Image Sensor||2020.09.24||49016|
|345||<Sep.23(Wed.)>나는 내 마음이야||2020.09.16||15688|
|343||2020학년도 2학기 콜로퀴움 일정||2020.07.16||151160|
|342||2020학년도 1학기 콜로퀴움 일정||2020.01.31||251313|
|341||<Dec.11(Wed.)>데이터 과학으로서의 물리학. 그리고 금융투자업||2019.12.04||39557|
|340||<Dec.4(Wed.)>2D materials based metasurfaces & THz near-field spectroscopy||2019.11.27||65267|
|339||<Nov.20(Wed.)>At the End of Space and Time: Imaging the Black Hole in M 87||2019.11.14||62197|
|338||<Nov.13(Wed.)>The Science of Quark-Gluon Plasma||2019.11.06||34838|
|337||<Oct.30(Wed.)> 왼손과 오른손, 기본 입자와 끈||2019.10.24||74353|
|336||<Oct.16(Wed.)> 솟구치는 초고에너지 입자의 미스테리||2019.10.10||101005|
|335||<Oct.2(Wed.)> Fundamental physics with high-energy atmospheric and cosmic neutrinos today and in the future||2019.09.26||62318|
|334||<Sept.18(Wed.)> Rare-earth: versatility and capability||2019.09.16||71447|
|333||<Sept.11(Wed.)> Fantastic physics and materials, how to find them?||2019.09.06||67625|
|332||2019학년도 2학기 콜로퀴움 일정||2019.07.17||421214|
|»||<June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices||2019.06.07||154441|
|330||<June.5(Wed.)> Fluid gravity duality||2019.05.29||55904|
|329||<May.22(Wed.)> Introduction to exotic quantum states in solids||2019.05.15||65888|
|328||<May.15(Wed.)> Three-body problems and three-body forces in Classic and Quantum Systems||2019.05.08||60499|
|327||<May.8(Wed.)> Genesis of Matter||2019.05.01||40548|