logo

korean english

게시판

Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.


4시 20분부터 제1과학관 31214 e+강의실에서 간단한 다과를 제공합니다.


                       아      래


Title: Ribocomputing: Cellular Logic Computation using RNA Devices


Speaker: 김  종  민 교수님 (포항공과대학교 생명과학과)


Date & Time: June. 12. (Wed.) 2019 4:30 PM


Place: Natural Science 1,  Room No. 31214


Abstract: Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. Despite many advances, technical challenges remain for scaling up the complexity of these networks due to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and substantial resource requirements for encoding and operation. Here, we report a strategy for constructing RNA-only nanodevices to evaluate complex logic in living cells. Such ‘ribocomputing’ systems are composed of de novo designed parts and operate via predictable and designable base-pairing rules, allowing for effective in silico design of computing devices with prescribed configurations and functions in complex cellular environments. We demonstrate that these ribocomputing devices in Escherichia coli can evaluate two-input logic expressions with dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and a complex 12-input logic expression [1]. Successful operation of ribocomputing devices based on programmable RNA interactions suggests that systems employing the same design principles could be implemented in other host organisms or in extracellular settings.

 

Input RNAs.jpg



References
[1] Green AA*, Kim J*, Ma D, Silver PA, Collins JJ, Yin P, Complex cellular logic computation using ribocomputing devices, Nature 548:117–121, 2017.

 

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1089640
336 <Oct.16(Wed.)> 솟구치는 초고에너지 입자의 미스테리 2019.10.10 146822
335 <Oct.2(Wed.)> Fundamental physics with high-energy atmospheric and cosmic neutrinos today and in the future 2019.09.26 71865
334 <Sept.18(Wed.)> Rare-earth: versatility and capability 2019.09.16 88965
333 <Sept.11(Wed.)> Fantastic physics and materials, how to find them? 2019.09.06 91325
332 2019학년도 2학기 콜로퀴움 일정 2019.07.17 428816
» <June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices file 2019.06.07 243446
330 <June.5(Wed.)> Fluid gravity duality 2019.05.29 68536
329 <May.22(Wed.)> Introduction to exotic quantum states in solids 2019.05.15 79836
328 <May.15(Wed.)> Three-body problems and three-body forces in Classic and Quantum Systems 2019.05.08 75722
327 <May.8(Wed.)> Genesis of Matter 2019.05.01 42175
326 <May.1(Wed.)> Introduction of AMS Application 2019.04.24 70044
325 <April.17(Wed.)> Emerging Artificial Synapse for Learning- and Energy-Efficient Neuromorphic System 2019.04.11 130437
324 <April.10(Wed.)> 자성 반데르발스 물질 발견과 전망(Discovery and Perspective of magnetic van der Waals materials) 2019.04.04 49103
323 <April.3(Wed.)> 전자구조계산을 이용한 새로운 양자물질 연구 2019.03.27 47712
322 <Mar.27(Wed.)> Ultrafast Movie Maker for Photo-induced Dynamics: Ultrafast Electron Microscope 2019.03.20 95324
321 <Mar.20(Wed.)> Connecting Thermoelectricity and Superconductivity by Pressure Bridge 2019.03.13 58525
320 <Mar.13(Wed.)> Physics in Medicine: Magnetic Resonance Imaging 2019.03.07 64250
319 2019학년도 1학기 콜로퀴움 일정 2019.01.08 129891
318 <Dec.12(Wed.)> First-principles studies of complex oxides interfaces 2018.12.05 66150
317 <Dec.5(Wed.)> 두 펄사 이야기 2018.11.28 162685