korean english


Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다. 4시 20분부터 제1과학관 31214 e+강의실 앞에서 다과를 준비하오니 많은 참석 부탁드립니다 아 래 제목: Modified nucleic acid systems for biomedical applications 연사: 김 병 현 교수 (포항공대 화학과) 일시: 2010년 11월 5(금) 오후4:30 장소: e+첨단강의실 (31214호실) 초록: Nucleic acid today can be viewed as a chemical reagent, quite apart from its role in biology, although much of the work is inspired by what might be the positive consequences for medicine or drug development or diagnosis of disease. For even neglecting its biological importance, there would still be a lot of interests in nucleic acid as a fundamental molecule for chemists to study and use as an object for chemical building blocks, sensing, polymer design and others.1 Nowadays, nucleic acids have been emerged from various research areas such as DNA computing, nano-size structures using DNA, sensors recognizing mRNA and DNA, and oligonucleotide therapeutics, and others.2 Chemical modification of nucleic acid systems is essential to obtain more effective and stable materials. From nucleoside to oligonucleotide, chemical modification is open to any part of nucleic acid. We focus on the synthesis of new phosphoramidites to incorporate into the oligonucleotides. In this seminar, we will discuss our research efforts into oligonucleotides functionalized with steroid derivatives and cationic amine moieties to enhance their cell permeability.3 We will also describe about our syntheses of modified oligonucleotides containing fluorescent tags for use as molecular probes (molecular beacons) to detect single-nucleotide polymorphisim (SNP) in nucleic acids,4 and to monitor secondary structures of various nucleic acids such as B-Z transition,5 G-quadruplex structures,6 and DNA i-motif structures. References 1. Henry, C. M. C&E News 2003, 81, 49-60. 2. (a) Seo, Y. J.; Rhee, H.; Joo, T.; Kim, B. H. J. Am. Chem. Soc. 2007, 129, 5244-5247. (b) Seo, Y. J.; Bhuniya, S.; Kim, B. H. Chem. Commun. 2007, 1804-1806. (c) Venkatesan, N.; Kim, B. H. Chem. Rev. 2006, 106, 3712-3761. 3. Seo, Y. J.; Jeong, H. S.; Bang, E. K.; Hwang, G. T.; Jung, J. H.; Jang, S. K.; Kim, B. H. Bioconjugate Chem. 2006, 17, 1151-1155. 4. (a) Venkatesan, N.; Seo, Y. J.; Kim, B. H. Chem. Soc. Rev. 2008, 37, 648-663. (b) Hwang, G. T.; Seo, Y. J.; Kim, B. H. J. Am. Chem. Soc. 2004, 126, 6528-6529. 5. Seo, Y. J.; Kim, B. H. Chem. Commun. 2006, 150–152. 6. (a) Seo, Y. J.; Lee, I. J.; Yi, J. W.; Kim, B. H. Chem. Commun. 2007, 2817-2820. (b) Seo, Y. J.; Lee, I. J.; Kim, B. H. Bioorg. Med. Chem. Lett. 2008, 18, 3910-3913.
번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1078187
605 <10/1(Tue.) Mini-Workshop on BSM Physics with Neutrino Detectors 2019.09.30 81494
604 <Oct.2(Wed.)> Fundamental physics with high-energy atmospheric and cosmic neutrinos today and in the future 2019.09.26 68360
603 <9/26(Thu.) 4:30 pm ~ > Neutrino Physics and Dark Matter search in IBS 2019.09.24 104893
602 <9/24(Tue) 4:00 pm ~ > Structure Formation with Two Periods of Inflation: Beyond plain LCDM 2019.09.17 50224
601 <Sept.18(Wed.)> Rare-earth: versatility and capability 2019.09.16 82431
600 <9/17(Tue) 4:00 pm ~ >Dynamics of multiple-Q spin textures and its effect on electronic state 2019.09.10 64184
599 <Sept.11(Wed.)> Fantastic physics and materials, how to find them? 2019.09.06 82803
598 <9/2(Mon) 15:00 ~ >Status of the KM3NeT Deep Sea Neutrino Telescope 2019.08.26 78227
597 <8/30(Fri) 16:00 ~ >Structures of light neutron-rich nuclei, 17,19C 2019.08.22 87201
596 <8/26(Mon) 14:00 ~ >Constructing viable models of bouncing scenarios 2019.08.20 57612
595 <8/19(Mon) 13:30 ~ >Detection of cosmic rays in the PeV to EeV energy range file 2019.08.16 90776
594 <8/14(Wed.)>3D-strain induced superconductivity in La2CuO4+δ using a simple vertically aligned nanocomposite approach 2019.08.13 68811
593 <8/19(Mon) 14:00 ~ >Exploring topological matter in an atomic quantum simulator file 2019.07.26 77201
592 2019학년도 2학기 콜로퀴움 일정 2019.07.17 426597
591 <June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices file 2019.06.07 237776
590 <June.5(Wed.)> Fluid gravity duality 2019.05.29 61931
589 <May.22(Wed.)> Introduction to exotic quantum states in solids 2019.05.15 75503
588 <May.15(Wed.)> Three-body problems and three-body forces in Classic and Quantum Systems 2019.05.08 71495
587 <5/16(Thu.) 14:00 ~ >The Chiral anomaly without Landau levels 2019.05.08 127262
586 <May.8(Wed.)> Genesis of Matter 2019.05.01 41715