logo

korean english

게시판

Home > 게시판 > 세미나

아래와 같이 세미나를 개최하오니 많이 참석해 주시기 바랍니다.

 

                    아       래

 

제목: Radioprotection effect and anti-tumor immunity by TCM-EF in mice

 

연사: 구  연  화  교수님 (일본, Junshin Gakuen University)

 

일시: 2013. 8. 20(화) 11am
 

장소: 물리학과 세미나실 (31355호실)
 

초록: Various previously intractable diseases have been overcome by the development of many new medicines. However, cancer is still a major cause of death. In the process of carcinogenesis, a multistep accumulation of gene mutations causes malignant transformation, and the probability of gene mutations is different depending on genetic and environmental factors. Individual differences are found in the susceptibility to cancer, and prevention of carcinogenesis is possible. In the lactic acid bacteria in the gut, we directed our attention to TCM-EF, which have been known as using the bacteria death of lactic acid bacteria by heat treatment, and examined the mechanisms by which these substances affect antioxidant activity, anti-tumor activity and immunoresponse.
When the antioxidant activities of TCM-EF were examined by the DPPH and Rhoudan iron methods, since TCM-EF contains high levels of β-glucan, it is thought that β-glucans may be responsible for the immunoenhancement activity in this study. In the examination of immunoenhancement activity, we measured lymphocyte versus polymorophonuclear leukocyte ratios (L/P activity) in the experimental animals. The number of lymphocytes was significantly increased in groups treated with Propolis as a control. Specifically, slightly high levels of IFN-γ were measured in mice bearing the S-180 carcinoma, after administration of TCM-EF. This strongly suggests that cellular immunity is especially activated by treatment with TCM-EF, because production of IFN-γ is known to be limited to the T cells and NK cells stimulated by mitogen and sensitized antigen. When TNF-α levels were measured in mice bearing the S-180 carcinoma, mice treated with TCM-EF showed slightly higher TNF-α levels as compared to the control group. This suggests that activated macrophages produce TNF-α in mice treated with TCM-EF, since activated macrophages and lymphocytes are the source of most TNF-α. When anti-tumor action was examined using two kinds of sarcoma of Ehrlich solid carcinoma and Sarcoma-180 carcinoma, tumor-suppressive ratios after treatment with TCM-EF was 60.3 % and 83.1 %, respectively. Thus, TCM-EF showed strong anti-tumor activity against two kinds of solid carcinoma. Taken altogether, this strongly suggests that TCM-EF enhances original functions of macrophages and NK cells, and as a result, secondarily enhances the immune reaction and suppresses tumor growth.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1089692
181 <4/6> Observation of Reactor Electron Antineutrino Disappearance in the RENO Experiment 2012.04.04 76683
180 <4/23> BK 석학초청 특별강연 - Connections between Stellar Evolution and Nuclear Physics 2012.04.16 78937
179 <4/18> Action-angle variables for the near-horizon extreme black hole particle dynamics 2012.04.17 118566
178 <4/24> How to introduce the monopole in quantum mechanics? 2012.04.23 77397
177 <5/1> Supersymmetry Breaking in Chern-Simons-matter Theories 2012.04.30 74238
176 <5/3> APOLLO Program: Understanding Neutron-Rich Nuclei for r-Process Nucleosynthesis 2012.05.03 99508
175 <5/8> A brief introduction to holographic entanglement entropy 2012.05.07 82755
174 <5/9> Gravity dual of (Non-)Fermi Liquids from Entanglement Entropy 2012.05.07 82033
173 <5/16> superconformal index with line operators and domain walls 2012.05.14 100022
172 <6/5> BK 석학초청 특별강연 - How Well Does High Field Specific Heat Probe the Nodal Nature of the Multi- 2012.05.14 101656
171 <5/22> Vortex partition function and 3d dualities 2012.05.21 69558
170 <6/5> Bilinear Wess-Zumino term for open AdS superstring: covariant description of D-branes 2012.06.04 108160
169 <6/19> 초전도 특별세미나 2012.06.11 101138
168 <6/19> Kohn's theorem and non-relativistic symmetry 2012.06.15 92601
167 <6/21> Nuclear Astrophysics in Effective Field Theories 2012.06.20 92304
166 <7월27일>Correlated topological phases in 3D complex oxides via Green's functions 2012.07.27 90509
165 <8/7> Scotch tape and spectroscopy: probing and manipulating the surface of a topological insulator 2012.07.27 94076
164 <9/7(금)> Kondo Effect in Chiral Orbital Bands 2012.08.31 69910
163 <9/7> On Dark Matter and its indirect detection with box-shaped gamma-rays 2012.09.05 75966
162 <9/14> High temperature superconductivity and fluctuating stripe 2012.09.10 105125