장소: 제1과학관 31214  e+첨단강의실 

초록: Recent advances in nucleic acid nanotechnology enable us to build complex three-dimensional
nucleic acid structures at the nanometer scale for diverse applications in materials and biological
science. Scaffolded DNA origami is a successful approach to folding DNA into programmed
one-, two-, and three-dimensional shapes. Predictive computational tools are essential to enable
the rational design of these structures that meet target design specifications. Here I will present a
physics-based computational modeling approach called CanDo (Computer-aided engineering for
DNA origami) as well as the basic design principles used in DNA origami nanotechnology.
CanDo employs the finite element method to predict equilibrium 3D solution shapes and thermal
fluctuation amplitudes that are validated experimentally for various DNA origami designs.
CanDo has been provided to the public as a web-based online tool (http://cando-dna-origami.org)
and extensively used by the broader scientific community.