korean english


Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다.

4시 20분부터 제1과학관 31214 e+강의실에서 간단한 다과를 제공합니다.

                       아      래

Title: Ribocomputing: Cellular Logic Computation using RNA Devices

Speaker: 김  종  민 교수님 (포항공과대학교 생명과학과)

Date & Time: June. 12. (Wed.) 2019 4:30 PM

Place: Natural Science 1,  Room No. 31214

Abstract: Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. Despite many advances, technical challenges remain for scaling up the complexity of these networks due to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and substantial resource requirements for encoding and operation. Here, we report a strategy for constructing RNA-only nanodevices to evaluate complex logic in living cells. Such ‘ribocomputing’ systems are composed of de novo designed parts and operate via predictable and designable base-pairing rules, allowing for effective in silico design of computing devices with prescribed configurations and functions in complex cellular environments. We demonstrate that these ribocomputing devices in Escherichia coli can evaluate two-input logic expressions with dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and a complex 12-input logic expression [1]. Successful operation of ribocomputing devices based on programmable RNA interactions suggests that systems employing the same design principles could be implemented in other host organisms or in extracellular settings.


Input RNAs.jpg

[1] Green AA*, Kim J*, Ma D, Silver PA, Collins JJ, Yin P, Complex cellular logic computation using ribocomputing devices, Nature 548:117–121, 2017.


번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1079302
666 <Sep. 15(Wed.)> 강화학습 - 시행착오를 통해 배워나가는 인공지능 2021.09.08 5551
665 <Oct. 6(Wed.)> 블랙홀에서 쌍꺼풀수술까지 2021.09.29 6145
664 <Nov. 29(Mon.)>Exploring light-matter interactions at atomic scale using electron microscopy 2021.11.22 8225
663 <Nov. 10(Wed.)>Optical Spectroscopy of 2-Dimensional Materials 2021.11.03 9475
662 <Nov. 3(Wed.)>시공간의 구조: 상대성이론, 특이점, 우주상수 2021.10.28 9971
661 <April 21(Wed.)> 우주배경복사 편광 관측 - 남극점 기지 바이셉/켁 어레이(BICEP/Keck Array) 망원경 2021.04.12 10154
660 <April 28(Wed.)> 손에 잡히는 AI 2021.04.21 10691
659 <Dec.9(Wed.)>한국형 암흑물질 실험 2020.12.02 15702
658 <Oct.14(Wed.)>New Ways to Search for the Dark World 2020.10.12 16138
657 <Sep.23(Wed.)>나는 내 마음이야 2020.09.16 16883
656 <Sep.16(Wed.)>Artificial Crystal 2020.09.14 19847
655 <Sep. 8(Wed.)> Utilizing physics to build a trapped-ion quantum computer 2021.09.01 23286
654 <May 12(Wed.)> Nanomechanical oscillators for quantum technology 2021.05.06 23422
653 <Mar.17(Wed.)> Glue spectrum for superconductivity obtained via optical spectroscopy 2021.03.10 28594
652 <July 21(Wed.)> Strongly Correlative Ionics 2021.07.19 29910
651 <Nov.11(Wed.)>Nonlinear optics to study charge, spin, and crystalline structures 2020.11.04 31060
650 <June 23(Wed.)>Valley Polarization and Exciton Hall Effect in Transition Metal Dichalcogenides 2021.06.22 31374
649 <Aug. 6(Fru.)> Gravitationally probing dark matter (DM) microphysics 2021.08.03 31501
648 <8/1(Sat.)> Recent Advances in Deep Learning 2020.07.29 35109
647 <Nov.13(Wed.)>The Science of Quark-Gluon Plasma 2019.11.06 36792