logo

korean english

게시판

Home > 게시판 > 세미나

콜럼비아대학교의 이자일 박사님을 초청하여 아래와 같이 특별 세미나를 개최합니다.

학과 구성원 여러분의 많은 참석을 부탁 드립니다. 

 

         아             래  

 

     1. 일시: 2013년 4월 30일(화) 오후 4시 30분 

 

     2. 장소: 제1과학관 기초과학연구소세미나실 31317호

 

     3. 연사: 이  자  일  박사님 (Columbia University

 

     4. 제목: DC (DNA Curtains) and AC (Actin Curtains) in single-molecule biophysics

 

     5. 초록: Single-molecule biophysics provides powerful tools for investigating in-depth biological phenomena that cannot be uncovered by conventional biophysical and biochemical methods. A variety of single-molecule methods have been developed and are rapidly expanding their realms. Here I introduce two novel single-molecule techniques, DNA curtains (DC) and actin curtains (AC), both of which provide in vitro platforms to study biopolymers and associated proteins based on the integration of lipid bilayer fluidity, microfluidics, total internal reflection fluorescence microscopy (TIRFM), and nano-technology. The advantages of these techniques are 1) visualizing individual bio-molecules in real time, 2) observing hundreds of bio-molecules within one field-of-view, which are responsible for the statistical reliability, and 3) offering a bio-compatible environment through the membrane bilayer. With the help of DNA curtains the activities of FtsK are examined, which is a DNA translocase moving along double-stranded DNA. The DNA curtains assay demonstrates that FtsK is assembled on a specific DNA sequence, translocates along DNA rapidly and processively, and displaces protein roadblocks during translocation. The results give an insight into the biological function of FtsK in the E. coli cell division and chromosome segregation. On the other hand, the actin curtains technique enables one to characterize actin filament growth by a formin, which enhances actin nucleation. Moreover, under the hydrodynamic flow, the polymerization of actin filaments increases force applied to the formins. This allows one to examine the force effect on the formin-mediated actin polymerization. Surprisingly, the force reduces the formin-mediated actin polymerization rate without any cofactor, whereas the polymerization rate is increased by force in the presence of a cofactor, profilin.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1060565
» <4/30(화)> DC (DNA Curtains) and AC (Actin Curtains) in single-molecule biophysics 2013.04.11 114043
101 <8/5>Brane superpotential via local Calabi-Yau spaces 2009.08.03 114203
100 <12/21(금)> Theory of topological quantum phase transitions in 3D noncentrosymmetric systems 2012.12.05 114220
99 <12/30> Dirac vs. Weyl in topological insulators: Adler-Bell-Jackiw anomaly in transport phenomena 2013.12.16 115211
98 <7/20(Thu.)14:00>Engineering and probing topological properties of Dirac semimetal films by asymmetric charge transfer 2017.07.18 115372
97 <7/25(목) 오전11시> 물리학과 특별세미나 개최 안내 2013.07.19 115561
96 <1/28> Steps towards a non-relativistic AdS/CFT 2010.01.25 115718
95 <5/15>Black Hole Entropy Function in (Anti-)de Sitter Space-Time 2008.05.09 116069
94 <3/31> ZnO nanorod heterostructures and nanodevices 2006.03.27 117297
93 <4/14> X-ray absorption fine structure analyses on amorphous oxide films 2009.04.06 117574
92 <5/16(Thu.) 14:00 ~ >The Chiral anomaly without Landau levels 2019.05.08 118323
91 <3/12(화)>물리학과 특별초청강연 개최 안내 2013.03.04 118338
90 <4/30> Updates on warped brane inflation 2009.04.21 118406
89 <11/5> Modified nucleic acid systems for biomedical applications 2010.11.01 119056
88 <3/19> Bioconjugates of nanomaterials for biochip & biosensor applications 2010.03.16 119773
87 <10/17> Graphitic Carbon Nanostructures 2008.10.27 120592
86 <5/1>In vivo optical imaging of hemodynamic changes 2009.05.06 121231
85 <4/4> Novel multi-bit magnetic tagging technique for high-throughput chemical analysis 2008.03.31 121481
84 <4/21> Experimental and Observational Astrophysics in the Infrared Wavebands 2009.04.17 121645
83 <10/28>Grazing Incidence X-ray Diffraction and Surface X-ray Scattering Study of Hematite (α-Fe2O3) Nano-cube 2011.10.26 121683