korean english


Home > 게시판 > 세미나

아래와 같이 세미나를 개최하오니 많이 참석해 주시기 바랍니다.


                    아       래


제목: Radioprotection effect and anti-tumor immunity by TCM-EF in mice


연사: 구  연  화  교수님 (일본, Junshin Gakuen University)


일시: 2013. 8. 20(화) 11am

장소: 물리학과 세미나실 (31355호실)

초록: Various previously intractable diseases have been overcome by the development of many new medicines. However, cancer is still a major cause of death. In the process of carcinogenesis, a multistep accumulation of gene mutations causes malignant transformation, and the probability of gene mutations is different depending on genetic and environmental factors. Individual differences are found in the susceptibility to cancer, and prevention of carcinogenesis is possible. In the lactic acid bacteria in the gut, we directed our attention to TCM-EF, which have been known as using the bacteria death of lactic acid bacteria by heat treatment, and examined the mechanisms by which these substances affect antioxidant activity, anti-tumor activity and immunoresponse.
When the antioxidant activities of TCM-EF were examined by the DPPH and Rhoudan iron methods, since TCM-EF contains high levels of β-glucan, it is thought that β-glucans may be responsible for the immunoenhancement activity in this study. In the examination of immunoenhancement activity, we measured lymphocyte versus polymorophonuclear leukocyte ratios (L/P activity) in the experimental animals. The number of lymphocytes was significantly increased in groups treated with Propolis as a control. Specifically, slightly high levels of IFN-γ were measured in mice bearing the S-180 carcinoma, after administration of TCM-EF. This strongly suggests that cellular immunity is especially activated by treatment with TCM-EF, because production of IFN-γ is known to be limited to the T cells and NK cells stimulated by mitogen and sensitized antigen. When TNF-α levels were measured in mice bearing the S-180 carcinoma, mice treated with TCM-EF showed slightly higher TNF-α levels as compared to the control group. This suggests that activated macrophages produce TNF-α in mice treated with TCM-EF, since activated macrophages and lymphocytes are the source of most TNF-α. When anti-tumor action was examined using two kinds of sarcoma of Ehrlich solid carcinoma and Sarcoma-180 carcinoma, tumor-suppressive ratios after treatment with TCM-EF was 60.3 % and 83.1 %, respectively. Thus, TCM-EF showed strong anti-tumor activity against two kinds of solid carcinoma. Taken altogether, this strongly suggests that TCM-EF enhances original functions of macrophages and NK cells, and as a result, secondarily enhances the immune reaction and suppresses tumor growth.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1090435
182 <8/7> Scotch tape and spectroscopy: probing and manipulating the surface of a topological insulator 2012.07.27 94236
181 <2/17(Mon.)> Magneto-optical study of the Dirac semimetal Cd3As2 in Voigt geometry 2020.02.11 94073
180 <2/15> Geometric distance-dependent percolations in networks on two-dimensional planes 2011.02.11 93786
179 <5/22> 정상욱 교수 초청 세미나 Overview of Multiferroics 2006.05.19 93687
178 <8/30(Fri) 16:00 ~ >Structures of light neutron-rich nuclei, 17,19C 2019.08.22 93439
177 <June 30(Wed.)>Mapping of magnetic anisotropy for van der Waals materials 2021.06.25 93034
176 <4/2> Supersymmetric vacua of mass-deformed M2-brane theory 2010.03.29 92893
175 <6/19> Kohn's theorem and non-relativistic symmetry 2012.06.15 92807
174 <6/21> Nuclear Astrophysics in Effective Field Theories 2012.06.20 92549
173 <8/17> Is Quantum Criticality a Key to Unconventional Superconductivity? 2006.08.09 92343
172 <11/4 오전 10:30> Quantum transport through topological-metal strip 2013.10.23 92320
171 <3/26>A perturbative & non-perturbative test of ABJM model 2009.03.19 92282
170 <8/7> Scotch tape and spectroscopy: probing and manipulating the surface of a topological insulator 2012.07.27 92238
169 <6/10> Traffic Problem in Physics and Its Application 2008.06.10 91975
168 <10/1(Tue.) Mini-Workshop on BSM Physics with Neutrino Detectors 2019.09.30 91798
167 <2/15> Perturbation during Inflation 2011.02.11 91742
166 <1/14>Dark Matter signals from PAMELA and ATIC 2009.01.12 91069
165 <3/16(Fri.)11:00> Superlattice phonons of two dimensional heterostructures 2018.03.16 90995
164 <3/13(금) pm1:00> 초청세미나 개최 안내 2015.03.09 90901
163 <2/16>Hamiltonian formalism 2011.02.11 90760