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아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다. 4시 10분부터 2층 라운지세미나실에 다과를 준비하오니 많은 참석 부탁드립니다 아 래 제목: In vivo optical imaging of hemodynamic changes as a surrogate signal of neuronal activity in the neocortex 연사: 서 민 아 교수(성균관대학교 생명과학과) 일시: 2009년 5월 1일(금) 오후4:30 장소: 물리학과 세미나실(31355호실) 초록: Optical imaging offers excellent spatio-temporal sensitivity that is unparalleled by any other perfusion based imaging techniques. We used in vivo optical recording of intrinsic signals (ORIS) to map neurovascular hemodynamics of perfusion, oximetry and membrane potential during epileptic events in rat and mouse neocortex. Studies of hemodynamic changes with ORIS alone were also performed in human. Laboratory studies in rodent epilepsy models have demonstrated a persistent increase in deoxygenated hemoglobin (Hbr) and a decrease in tissue oxygenation during interictal spikes and ictal events. This “epileptic dip”, like the “initial dip” recorded during normal sensory processing, implies that the enormous rise in cerebral blood flow (CBF) is inadequate to meet the increased metabolic demands associated with synchronized epileptic activity. These findings are critically important to the interpretation of the perfusion-based imaging studies, such as fMRI. In addition, we visualized the effect of direct cortical electrical stimulation, an alterative epilepsy treatment. The optical data following direct cortical electrical stimulation showed that hemodynamic signals are sensitive to different electrical stimulation parameters. Furthermore, our recent data demonstrated that the application of unilateral electrical stimulation is able to elicit bilateral hemodynamic responses in rat neocortex. 자료를 다운 받으시려면 아래의 링크을 클릭해주세요. http://physics.skku.ac.kr/ppt/090501.ppt
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