korean english


Home > 게시판 > 세미나

아래와 같이 콜로퀴움을 개최하오니 많이 참석해 주시기 바랍니다. 4시 20분부터 제1과학관 31214 e+강의실 앞에서 다과를 준비하오니 많은 참석 부탁드립니다 아 래 제목: Modified nucleic acid systems for biomedical applications 연사: 김 병 현 교수 (포항공대 화학과) 일시: 2010년 11월 5(금) 오후4:30 장소: e+첨단강의실 (31214호실) 초록: Nucleic acid today can be viewed as a chemical reagent, quite apart from its role in biology, although much of the work is inspired by what might be the positive consequences for medicine or drug development or diagnosis of disease. For even neglecting its biological importance, there would still be a lot of interests in nucleic acid as a fundamental molecule for chemists to study and use as an object for chemical building blocks, sensing, polymer design and others.1 Nowadays, nucleic acids have been emerged from various research areas such as DNA computing, nano-size structures using DNA, sensors recognizing mRNA and DNA, and oligonucleotide therapeutics, and others.2 Chemical modification of nucleic acid systems is essential to obtain more effective and stable materials. From nucleoside to oligonucleotide, chemical modification is open to any part of nucleic acid. We focus on the synthesis of new phosphoramidites to incorporate into the oligonucleotides. In this seminar, we will discuss our research efforts into oligonucleotides functionalized with steroid derivatives and cationic amine moieties to enhance their cell permeability.3 We will also describe about our syntheses of modified oligonucleotides containing fluorescent tags for use as molecular probes (molecular beacons) to detect single-nucleotide polymorphisim (SNP) in nucleic acids,4 and to monitor secondary structures of various nucleic acids such as B-Z transition,5 G-quadruplex structures,6 and DNA i-motif structures. References 1. Henry, C. M. C&E News 2003, 81, 49-60. 2. (a) Seo, Y. J.; Rhee, H.; Joo, T.; Kim, B. H. J. Am. Chem. Soc. 2007, 129, 5244-5247. (b) Seo, Y. J.; Bhuniya, S.; Kim, B. H. Chem. Commun. 2007, 1804-1806. (c) Venkatesan, N.; Kim, B. H. Chem. Rev. 2006, 106, 3712-3761. 3. Seo, Y. J.; Jeong, H. S.; Bang, E. K.; Hwang, G. T.; Jung, J. H.; Jang, S. K.; Kim, B. H. Bioconjugate Chem. 2006, 17, 1151-1155. 4. (a) Venkatesan, N.; Seo, Y. J.; Kim, B. H. Chem. Soc. Rev. 2008, 37, 648-663. (b) Hwang, G. T.; Seo, Y. J.; Kim, B. H. J. Am. Chem. Soc. 2004, 126, 6528-6529. 5. Seo, Y. J.; Kim, B. H. Chem. Commun. 2006, 150–152. 6. (a) Seo, Y. J.; Lee, I. J.; Yi, J. W.; Kim, B. H. Chem. Commun. 2007, 2817-2820. (b) Seo, Y. J.; Lee, I. J.; Kim, B. H. Bioorg. Med. Chem. Lett. 2008, 18, 3910-3913.
번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1079610
686 2019학년도 2학기 콜로퀴움 일정 2019.07.17 426925
685 <12/3> Magnetic couplings, optical spectra, and spin-orbit exciton in 5d Mott insulator Sr2IrO4 2012.11.26 407053
684 <Mar.3(Wed.)>Scaling laws in Natural Language Processing 2021.02.25 346026
683 2017학년도 1학기 콜로퀴움 일정 2017.01.05 309881
682 <10/25> Wave properties of dipole-exchange spin waves in confined magnetic thin films 2006.10.25 297263
681 <5/16> 물리학자가 바라 본 단백질: 왜, 어떻게 연구하는가? 2012.05.10 270336
680 <6/11> Advanced Physiological Optics and Its Ophthalmic Applications 2014.05.28 260354
679 2020학년도 1학기 콜로퀴움 일정 2020.01.31 254740
678 BK 석학초청 특별세미나 - Frustration and dimensional reduction in multi-orbital systems 2011.10.28 253296
677 <3/14>Adaptive Optics for the Human Eye and Ophthalmic Applications 2008.03.12 249028
676 <6/17> Oscillating Fuzzy Sphere and M5/anti M5 configurations in ABJM model 2009.06.16 248290
675 <8/30(Wed.)10:30>​Technology convergence and applications of Large-Area Electronics, e-Textiles, bio-sensors and bio-electronics 2017.08.29 245266
674 <12/21> Special Seminar by Professor Ilya Vekhter 2010.11.30 245213
673 <11/6> Graphene plasmon and Plasmonics 2013.10.31 240922
672 <June.12(Wed.)> Ribocomputing: Cellular Logic Computation using RNA Devices file 2019.06.07 238725
671 <Jan.14(Thu.)>Oxygen sponge effects for epitaxial manganite thin film design 2021.01.11 237098
670 <11/5(화)> 특별세미나 개최 안내 2013.11.01 230451
669 <5/16(토)> 세미나 개최 안내 2015.05.18 217710
668 <Sep. 23(Wed.) 4:30 PM>Grain boundary effect in Metal : A journey of discovery from crystal to thin films without grain boundaries 2015.09.16 209503