logo

korean english

게시판

Home > 게시판 > 세미나

아래와 같이 세미나를 개최하오니 많이 참석해 주시기 바랍니다.

 

                    아       래

 

제목: Radioprotection effect and anti-tumor immunity by TCM-EF in mice

 

연사: 구  연  화  교수님 (일본, Junshin Gakuen University)

 

일시: 2013. 8. 20(화) 11am
 

장소: 물리학과 세미나실 (31355호실)
 

초록: Various previously intractable diseases have been overcome by the development of many new medicines. However, cancer is still a major cause of death. In the process of carcinogenesis, a multistep accumulation of gene mutations causes malignant transformation, and the probability of gene mutations is different depending on genetic and environmental factors. Individual differences are found in the susceptibility to cancer, and prevention of carcinogenesis is possible. In the lactic acid bacteria in the gut, we directed our attention to TCM-EF, which have been known as using the bacteria death of lactic acid bacteria by heat treatment, and examined the mechanisms by which these substances affect antioxidant activity, anti-tumor activity and immunoresponse.
When the antioxidant activities of TCM-EF were examined by the DPPH and Rhoudan iron methods, since TCM-EF contains high levels of β-glucan, it is thought that β-glucans may be responsible for the immunoenhancement activity in this study. In the examination of immunoenhancement activity, we measured lymphocyte versus polymorophonuclear leukocyte ratios (L/P activity) in the experimental animals. The number of lymphocytes was significantly increased in groups treated with Propolis as a control. Specifically, slightly high levels of IFN-γ were measured in mice bearing the S-180 carcinoma, after administration of TCM-EF. This strongly suggests that cellular immunity is especially activated by treatment with TCM-EF, because production of IFN-γ is known to be limited to the T cells and NK cells stimulated by mitogen and sensitized antigen. When TNF-α levels were measured in mice bearing the S-180 carcinoma, mice treated with TCM-EF showed slightly higher TNF-α levels as compared to the control group. This suggests that activated macrophages produce TNF-α in mice treated with TCM-EF, since activated macrophages and lymphocytes are the source of most TNF-α. When anti-tumor action was examined using two kinds of sarcoma of Ehrlich solid carcinoma and Sarcoma-180 carcinoma, tumor-suppressive ratios after treatment with TCM-EF was 60.3 % and 83.1 %, respectively. Thus, TCM-EF showed strong anti-tumor activity against two kinds of solid carcinoma. Taken altogether, this strongly suggests that TCM-EF enhances original functions of macrophages and NK cells, and as a result, secondarily enhances the immune reaction and suppresses tumor growth.

번호 제목 날짜 조회 수
공지 <12/8(Thu.) 11:00am>노벨상 소개 강연 - 2016년 노벨 물리학상: 위상 응집 물리의 탄생 2016.11.28 1078798
646 <5/23> 나노구조 산화물 재료의 기능성-용매화전자에서 전자화합물까지... 2012.05.17 164535
645 <4/18> 삼중항 여기자를 이용한 유기광전소자 연구 2012.04.05 163896
644 <11/5> Discussion on recent observation of cosmological dipole of alpha 2010.11.04 162566
643 <5/26>BK21 물리연구단 석학초빙 특별 세미나 2010.05.17 162166
642 <Dec.5(Wed.)> 두 펄사 이야기 2018.11.28 161576
641 2020학년도 2학기 콜로퀴움 일정 2020.07.16 161305
640 <11/13> Manmade Elements 2009.11.10 160701
639 <June 10(Thu.)>Oxide electronics utilizing spin-orbit coupling 2021.05.31 159987
638 <11/2> Color Science for Reflective mode Optical Shutter 2011.10.27 157033
637 <7/9> Strange Metallic Behavior in Anisotropic Background 2010.07.01 156805
636 <9/15> Resistance Switching Behavior of Epitaxially Grown NiO Thin Films 2009.09.07 156004
635 <9/25> 청각의 물리학: 어떻게 노이즈를 극복하는가? 2013.09.16 154297
634 <5/22> Semiconductor Nanomaterials for Unusual Format Electronics 2009.05.18 153723
633 <5/22> Computer-based Mathematical Analysis and Applications to Physics (컴퓨터 기반 수리해석과 물리학에의 응용) 2013.05.15 150856
632 <6/25(화)>물리학과 특별세미나 개최 안내 2013.06.24 150069
631 <10/27> 'Brain dynamics underlying human decision-making' 2006.10.21 148821
630 <11/27> Energy Amplifier Systems:Simulation and Experiments in the Field 2009.11.23 148376
629 <10/8>"Einstein was wrong?"--Two-proton spin- correlation measurement for EPR paradox. 2010.10.04 148316
628 <April 7(Wed.)> Mid-scale facilities for condensed matter research: high magnetic field and neutron scattering 2021.03.31 143778
627 <4/6> Knowledge is power: Maxwell's demon in the quantum wonderland 2011.03.31 142995